Have you ever heard of a tick causing an anaphylactic reaction to red meat?  Me neither.  But that is just what happened on Saturday June 4, 2016 in rural North Carolina.  A 36 year-old male, who just happened to be an emergency room (ER) nurse, presented at the ER with symptoms of an anaphylactic reaction.  He denied any previous allergic reactions, recent bee stings or medication changes, but his blood pressure was 70/30 mmHg and he was complaining of lightheadedness with a slow onset of urticaria.  The ER administered IM epinephrine, an anti-histamine, three liters of normal saline and steroids before the patient reported relief.


A week later, the patient followed-up with an allergist who asked about tick bites and red meat consumption, both of which the patient confirmed.  The physician ordered a blood serum test looking for antibodies to galatose-alpha-1, 3-galactose (alpha-gal).  The test came back positive.  In the early 2000’s, in the Southeastern part of the United States it was determined that alpha-gal, aka meat allergy, antigens are present in all non-primate mammals.  The culprit of the transmission was identified as the Lone Star Tick, which feeds on other mammals and then introduces the antigen to humans, resulting in an anaphylactic reaction to red meat.  The cause often goes unrecognized by emergency physicians because the reaction occurs hours after eating meat, as alpha-gal does not enter the bloodstream for several hours after the tick bite.


So in the future, if you have an anaphylactic patient without an identifiable cause, ask about recent tick bites and consumption of red meat or pork within the last six hours.  If alpha-gal is the cause it is recommended the patient avoids red meat and pork for at least two years and then be tested for the IgE antibodies to alpha gal.  Can you imagine no bacon or steak for at least two years?  The horror!!!


Alpha-gal.org. (2012). Alpha-Gal Allergy Awareness. Retrieved on June 10, 2016 from http://alpha-gal.org.


Platts-Mills, T. (2016, June 7). Anaphylaxis: Meat Eaters Are Getting Ticked.  Retrieved on June 10, 2016 from http://epmonthly.com/article/meat-eaters-getting-ticked-off/.




Richard Main, M.Ed., NRP, EMS Instructor
Richard has been in EMS since 1993 obtaining his EMT from Johnson County Community College.  He lived in Arizona and worked in private EMS and for a fire department in Southern Arizona for 10 years.